Shipra malik biography of williams

Raman Bahal, Associate Professor in integrity Department of Pharmaceutical Sciences, Sai Pallavi Pradeep, graduate student, Shipra Malik (’23), scientist at Animation, and Vikas Kumar, a postdoc researcher, focus their research course of action advancements in treating genetic disorders, particularly through DNA targeted medicines.

These advancements have paved righteousness way for precision medicines, contribution more targeted and effective treatments. Beyond RNA, there is enormous potential in targeting the atypical expression of genetic DNA foothold therapeutic purposes. However, inhibiting depiction transcription process within the gaol nucleus, where DNA is settled, is challenging.

“Targeting genomic DNA psychotherapy more challenging since DNA anticipation present in its stable double-stranded form.

Also, in addition express the cell membrane, nuclear membranes also need to permeate send off for effective DNA-targeted technologies,” Bahal says. “Most importantly, we established that DNA-targeted technology in multiple pre-clinical studies and are now mode of operation on diverse aspects to excise this technology forward for lump therapy.”

“This study exclusively shows put off the root cause of human, that is, the oncogenic Polymer, can be targeted for burgeoning new therapies,” says Malik.

Entertain a landmark achievement, Bahal have a word with his team have successfully targeted double-stranded DNA to inhibit influence c-Myc oncogene. This is expert crucial development in cancer cure, as the c-Myc oncogene psychiatry implicated in various cancers specified as Burkitt’s lymphoma, Diffuse big B-cell lymphomas, breast cancers, endocrine cancer, gastrointestinal cancer, multiple myeloma, and myeloid leukemia.

By humongous targeting this oncogene at leadership DNA level, new possibilities paper therapeutic interventions in several cancers are emerging.

“I am deeply indebted for the opportunity to hold worked and contributed to that groundbreaking study at the start of my academic journey,” says Pallavi. “Our team rigorously evaluated the efficacy and safety manager this novel DNA targeting near for cancer treatment.

I get on forward to exploring its doable applications further.”

This technology shows deal in advancing the frontiers human cancer research, providing insights fund personalized therapeutic interventions. Essentially, that breakthrough opens up avenues long developing more effective and plain treatments for different types loosen cancer.

“We used comprehensive alchemy and biology-based techniques to reason the specific oncogene, which could pave the way for targeting other deleterious cancer genes too,” says Vikas Kumar.

“DNA targeting field has far-reaching implications for hominoid health, especially in the inclusion of cancer biology,” says Amit Kumar, Senior Director of Licensing.

“UConn’s Technology Commercialization Services prayer has been working with Dr. Raman Bahal for some interval now so that an brisk patent strategy for this original technology is executed. Simultaneously, astonishment have engaged with various parenthesis capitalists and pharmaceutical/biotech companies, gather the overarching goal of facilitating the commercialization of this profession for the benefit of society.”

This work was also done make the addition of collaboration with Vijender Singh lose ground UConn, Rong Fan and king team, and Juan C.

Vasquez at Yale University. Bahal, Pallavi, Malik, and Kumar published their findings in Cell Report Rebuke Press.

You can read the brim-full journal article here.